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Do you use lenalidomide for patients with MDS with 5q- without other cytogenetic abnormalities but with one or more mutations on NGS?

Are there certain mutations that would lead you to avoid use of lenalidomide, for example, TP53?
1 Answer
Mednet Member
Mednet MemberInvited Expert
Hematology · University of Chicago
Answered on

For patients who meet the definition of del(5q) syndrome, I typically utilize lenalidomide regardless of the molecular features of the disease. The original publication (List et al., PMID 15703420), the phase III MDS-004 study (Fenaux et al., PMID 21753188), and the phase III SintraREV study (Díez-C...

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