What is your approach to using clonidine for anxiety?

It definitely helps in patients with autism with anxiety, 0.1 mg po bid but not my first line because of the blood pressure drop or rebound. I don’t use it as a first line for anxiety, as I haven’t seen any improvement if it’s just used for anxiety.

Strattera has some evidence for anxiety in autism,...

My first question would be to clarify what is meant by "anxiety." Anxiety is a normal and adaptive response in humans; we all have anxiety! Pathological anxiety, such as that meeting criteria for GAD, social phobia, etc., typically responds best to psychotherapy interventions (such as CBT) with or w...