Do you use minimum cutoff values for any PFTs below which you would not offer conventionally fractionated chemoradiation or SBRT for NSCLC?
Are pre-treatment PFTs actually correlated with treatment-related toxicity? If no absolute cutoff, do you have an ideal lower limit for PFTs?
Answer from: Radiation Oncologist at Academic Institution
We have historically not used a cut-off lower-limit for FEV1 or DLCO when selecting patients for SBRT for stage I NSCLC. This is supported by both our own (PMID 19487961) and the Indiana University (PMID 18394819) series in which patients were divided into quartiles by baseline PFT's. In b...
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Answer from: Radiation Oncologist at Academic Institution
The beauty of SBRT is that there are no PFT cutoffs and even patients who require oxygen via nasal cannula are candidates. That being said, my experience is that these oxygen-dependent patients are the ones that are more likely to run into complications with radiation pneumonitis or decline in resp...
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Radiation Oncologist at CCare
Do you use any particular cutoff for DLCO for conv...
Do you use any particular cutoff for DLCO for conv...
Answer from: Radiation Oncologist at Community Practice
No.