Do you use oral fosfomycin as a treatment option for uncomplicated cystitis due to ESBL producing E coli?

Fosfomycin is one of the first-line drugs for uncomplicated UTI listed in the Infectious Diseases Society of America (IDSA) UTI treatment guidelines (these guidelines are currently being updated). It is the only single-dose drug approved for UTI and is an effective option. It does have activity against some ESBL strains of E. coli - but so do other first line agents such as nitrofurantoin and pivmecillinam. Nitrofurantoin is my choice for treatment of uncomplicated UTI as its safety profile has ...