Do you use platinum therapy in BRCA1 mutated patients with ER/PR positive disease receiving neoadjuvant chemotherapy?

Topics: Breast Cancer • Medical Oncology • HR+

Answer from: Medical Oncologist at Academic Institution

In the absence of any data (of which I am aware) of benefit from adding a platinum analog to neoadjuvant chemotherapy in BRCA1-mutated patients with ER-positive/HER2-negative cancers (other than those with minimal ER expression, whom I treat as I do patients with triple-nega...

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Medical Oncologist at Foundation Medicine
I would agree that it’s a discussion especially ...

Answer from: Medical Oncologist at Academic Institution

I agree with Dr. @Sikov that there aren't significant data to support the routine use of platinum salts in this setting. In GeparSixto which focused on TNBC patients, the subset analysis in gBRCA mutated patients did not show a benefit to adding platinum over non-platinum chemotherapy. (Hahnen et al...

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