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Do you use SGLT2 inhibitors in the management of SIADH?

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Mednet Member
Mednet Member
Nephrology · UCLA

The osmotic diuresis induced by SGLT2 inhibitors results in the urinary excretion of water in excess of Na+ and K+ excretion, thereby resulting in an increase in the serum sodium concentration. However, SIADH is a clinical disorder characterized by an increase in TBW in the setting of relatively nor...

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Mednet Member
Mednet Member
Nephrology · Ohio State University Medical Center

I have utilized SGLT2 inhibitors in the management of SIADH in the past. As Dr. @Dr. First Last mentions, the natriuresis associated with SGLT2 inhibitors, but it doesn't lead to a durable natriuresis (likely because of its effect early in the tubule) compared to say loop diuretics (ie that's why we...

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Do you use SGLT2 inhibitors in the management of SIADH? | Mednet