Not always. While I will use meningitis dosing for initial therapy, I have no qualms about using cefazolin for MSSA (and several recent publications support this), nor using ceftriaxone 2g/d for streptococcal infection. And frequently after the initial 3-4 weeks on IV, I transition to oral doxycycli...

I do use meningitis-type dosing of antibiotics when treating epidural abscesses because of the concern of localized meningitis in the epidural space. Since many or most epidural abscesses that I have taken care of are from Staph aureus, I have traditionally used Nafcillin or Oxacillin if MSSA and Va...

Of course, I use meningitis-type dosing in patients with SEA or suspected SEA. Why wouldn't I? It's not to penetrate the meninges; it's a coincidence. For any abscess, I use increased dosing to penetrate the abscess. I agree with Dr. @Bradsher. Most SEAs I have treated are secondary to aureus. And, ...

Meningitis dosing.