Please select the option that best describes you:
Topics:
Rheumatology • Fibromyalgia • Neurology • Psychiatry • Pain Medicine • General Outpatient Psychiatry
Do you view the difference between oral and sublingual cyclobenzaprine as clinically significant?
Will you try the sublingual formulation in a patient who has failed the oral formulation, or vice versa?
Answer from: at Academic Institution
The potential advantage of sublingual vs oral cyclobenzaprine is likely related to less adverse side effects, especially early morning sedation. Therefore, I would consider trying the sublingual form in FM patients who failed the oral form, especially because of adverse side effects. I likely would ...
Sign In or Register to read more
Answer from: at Community Practice
Cyclobenzaprine has a 30–40 year track record in the treatment of fibromyalgia. For many patients, the primary limitation is not efficacy but tolerability.
There are no head-to-head trials comparing oral and sublingual cyclobenzaprine. The clinically meaningful difference between the two form...
Answer from: at Community Practice
Yes. Oral cyclobenzaprine—a TCA analogue structurally identical to amitriptyline aside from a single double bond—has been used off-label for fibromyalgia for many years. Despite long-standing anecdotal benefit, a prospective placebo-controlled RCT showed only transient improvement at 4 w...