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Topics:
Breast Cancer • Radiation Oncology
Does a high genomic risk score impact your radiation fields for patients with breast cancer?
For example, would a high Oncotype warrant treating with RNI in a patient who would otherwise be treated with high tangents?
Answer from: Radiation Oncologist at Community Practice
Agree with @Sushil Beriwal.
In SLN-negative situations with high scores, I would favor whole breast (rather than PBI). High genomic risk scores have been correlated with increased LRR.
Elegant summary recently presented by @Corey Speers,
ASTRO – Session EDU23.
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Answer from: Radiation Oncologist at Community Practice
There aren't prospective randomized data to support this, but I do use Oncotype to help me decide when to apply EORTC 22922 to offer RNI for medial, node-negative cancers. Although the trial was negative for its primary endpoint of overall survival, I a) find the absolute reduction in breast cancer ...