Does aspirin dose (81 mg vs 325 mg) matter for secondary stroke prevention?

This topic has been debated extensively. There are two camps in this debate:

1. Aspirin with a dose of 81 mg is adequate for platelet inhibition in the general population.
2. Aspirin with a dose of 325 mg may be needed for individuals who weigh more (>70 kg) to achieve appropriate platelet inhibition.

T...