Does baseline facial dermatitis in a patient with AD cause hesitation when starting Dupixent due to conjunctivitis-related complications, especially when there are many available options?   

Yes, I definitely do consider this. Not necessarily because of conjunctivitis but because I’ve seen a significant number of patients with “dupilumab facial redness or reaction” with out-of-proportion head/neck flaring in AD patients. In patients with significant facial involvement ...

I agree with Dr. @ Dasilva completely. I definitely take it into account, but not because of conjunctivitis. My opinion is that the literature has shown that head and neck AD is largely an overlap with seborrheic dermatitis and that IL-4 inhibition can cause an immune shift towards Th22, which ...