Does isolated del(5q) have the same prognostic implications for post-PV secondary myelofibrosis as it does in MDS?

Karyotypic abnormalities are rare in PV and ET. Abnormalities in myelofibrosis (MF) that are associated with an inferior prognosis are: 20q-, 13q-, +9, chromosome 1 translocation/duplication, -Y or sex chromosome abnormality other than –Y. There are few reports of del5q in MPN in general and not enough data to know if MF patients (either primary or secondary) with anemia have similarities to patients with MDS and an isolated del(5q). Patients with MF and isolated anemia can be treated with lenalidomide and thalidomide, similarly to MDS patients (and in particular those with del5q) however, no karyotype abnormality has been associated with likelihood of response.