Does IVIG or subcutaneous Ig interfere with monoclonal antibody therapy (i.e. dupilumab, infliximab, rituximab, etc)?

I definitely agree with Dr. @Dr. First Last concerns.

For what it’s worth, I use a lot of IVIG in combination with monoclonal medications in my myositis clinic, and have anecdotally noted multiple instances in which I feel that the efficacy of one of those monoclonals seems to have been worse when t...

This is a challenging question, but the answer is probably yes. One of the mechanisms of action of IVIG is thought to be increasing the metabolism of IG, which then would theoretically decrease the efficacy of any monoclonal therapy administered after. There is some evidence for this being true, at ...