Does the presence of a POLE mutation in endometrial cancer guide your recommendations regarding adjuvant radiation?
Answer from: Radiation Oncologist at Community Practice
It’s part of PORTEC 4 study to randomize patients to adjuvant RT based on molecular subtype. They are exploring if observation is suitable option for POLE type
Outside of a trial we still decide based on stage and grade for adjuvant treatment and not on molecular subtype.
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