Does the presence of multifocal disease impact your decision on whether or not to recommend post-mastectomy radiation?
Yes, it does however multifocality is just one of several risk factors that predict for the likelihood of local recurrence and it is far less important than % nodal positivity, tumor size, age, +margin, multicentricity or adequacy of lymph node dissection.
By itself, the presence of multifocality i...
This recently published article from Lancet address the role of post-mastectomy radiation therapy.
"Postmastectomy Radiotherapy: An American Society of
VOLUME 34 • NUM...
The data doesnt suggest multifocality by itself increases risk of relapse after mastectomy. One retrospective data from MDA suggest 1-3 positive node with multicentricity ( in different quadrant) increases LRR to more than 20% and sometimes we do cosider that as a factor in 1-3 positive node