Does tolerance of prior BTKi therapy or specific agent used (e.g., ibrutinib, acalabrutinib) influence your starting dose of pirtobrutinib?

For a patient experiencing tolerability concerns on prior covalent BTKi, how would you approach subsequent treatment with pirtobrutinib?

• No change, will start pirtobrutinib at standard dose of 200mg/day
• Would start pirtobrutinib at lower dose (150mg/day) and titrate up as tolerated
• Would start pirtobrutinib at lower dose (100mg/day) and titrate up as tolerated
• Would start pirtobrutinib at lower dose (50mg/day) and titrate up as tolerated
• I would not use pirtobrutinib for patients with tolerability concerns on prior covalent BTKi
• Other