Does variable allele frequency (VAF) of JAK mutation affect your clinical decision-making in MPN in any scenario?

If they have a very low JAK2 (i.e. <1%) and erythrocytosis or thrombocytosis, I always make sure to look for another possible cause. A bone marrow biopsy may be helpful (and I agree with Dr. @Dr. First Last that it is a good thing to do in all MPN patients). In patients with erythrocytosis and a low...

The JAK2 driver mutation quantitative allele burden is an important feature in the clinical management of PV, ET, and PMF patients. First, however, some prefatory comments: All MPN driver mutations are classified as variant because they contain a change in their DNA not normally found in the particu...

No, the VAF of JAK2V617F does not influence my decision to perform a marrow in MPNs.