Due to the high incidence of hyperlipidemia secondary to lorlatinib, do you recommend empiric statin therapy to all patients without known contraindications upon initiation of lorlatinib?
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Do you recommend empiric statin therapy to all patients when starting lorlatinib?
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2 Answers
Mednet Member
Medical Oncology · Moffitt Cancer Center
Answered on
I do not empirically start statin therapy. However, I will check lipid and triglyceride levels prior to initiation of lorlatinib and periodically (every 3-6 months) thereafter. I will initiate or change statins in patients where we see a rise in lipids and triglycerides. I will aim for a level that ...
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Mednet Member
Medical Oncology · Virginia Cancer Specialists (VCS) Research Institute
Answered on
I do not. Every drug has side effects, and with close monitoring (every few weeks for a few months), having them come back to check labs and start when it's elevated has little downside.
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