Mednet Logo

Excluding CLL, in which patients would you screen for hypogammaglobulinemia?

Solid tumor patients, other hematologic malignancies, patients with autoimmune diseases on immunosuppressive therapy? Do you consider workup if they are admitted with infectious complications not directly due to their cancer therapy (e.g. not neutropenic, leukopenic). If IgG <400, would you consider IVIG treatment for acute infections, even in the inpatient setting?
1 Answer
Mednet Member
Mednet MemberInvited Expert
Hematology · USC Keck School of Medicine
Answered on

Patients I screen for hypogammaglobulinemia include those with: gammaglobulin gap (total protein-albumin) less than two; advanced multiple myeloma or mantle cell lymphoma; patients who have received CAR T cells or bispecific antibodies against BCMA or CD20.

Join for free or sign in to see the full answer