For 5 fraction lung SBRT, is 11 Gy per fraction superior to 10 Gy per fraction?
The BED10 for 50 Gy in 5 fractions is 100, which is significantly lower then the BED of the 54 Gy in 3 fractions regimen (151). Since the Kestin/Grills paper (PMID#24630539) showed better local control with a BED10>105, should we be pushing the dose to 55 Gy in a 5 fraction plan?
2 Answers
Mednet MemberInvited Expert
Radiation Oncology · Cleveland Clinic
Answered on
I will make this brief. Until the results of the prospective dose escalation study RTOG 0813, I would not make any definitive statements on the appropriateness of dose escalation in the setting of lung SBRT. This not only has to do with establishing whether there truly is a dose response phenomenon ...
Join for free or sign in to see the full answer
Mednet MemberInvited Expert
Radiation Oncology · University of Washington School of Medicine
Answered on
A higher dose may be necessary for lung oligometastases. Norihisa e tal. published a series:
Stereotactic body radiotherapy for oligometastatic lung tumors.
Norihisa Y, Nagata Y, Takayama K, Matsuo Y, Sakamoto T, Sakamoto M, Mizowaki T, Yano S, Hiraoka M.
Int J Radiat Oncol Biol Phys. 2008 Oct 1;72(2):...
Join for free or sign in to see the full answer