For a cystic lung tumor <5cm, are there any special SBRT planning considerations that you consider as compared to a solid lung tumor?

I don't typically change much about SBRT planning for cystic lung tumors, besides being particularly cognizant of any interfraction changes on the CBCT. In my experience, I haven't yet noticed major differences in outcomes for these tumors. I am not familiar with literature specifically asking this question but this would certainly be an interesting research topic.

Agree with @Dr. First Last. We would treat it with the same goal of achieving BED > 100, ideally > 130 when feasible. Though, it would be interesting to compare outcomes to solid tumors with similar size/volume. I would anticipate outcomes in these non-solid/cystic lesions to be as good if not better than solid lesion from a biological perspective but also from a decrease in density and # of malignant cells perspective.

From a physics perspective, I supposed that there may be some uncertainty i...