For a patient s/p TORS with indications for adjuvant radiation, how does your management change with persistently elevated ctHPVDNA?  

At this time, it's a bit challenging to make any meaningful treatment changes based on positive post-operative ctHPVDNA. But it certainly raises my suspicion - I would take a close look at the CT simulation for any potential grossly positive nodes (especially a retropharyngeal node that may not have...

Poorer prognosis. Mayo surgical data suggests that these patients, unfortunately, have lower cancer control. Need more data, though. I wouldn't change management. I agree with being more vigilant with looking for gross disease on your CT sim and making sure the distant staging scans are "current."&n...

I don’t think that at this point it changes your management, but it can be used post-treatment to monitor response.