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For a patient with locally current endometrial cancer whose disease had complete radiographic response to carboplatin, Taxol, and pembrolizumab, would you consider adding radiation therapy?
She had a resected FIGO grade 2 endometrioid adenocarcinoma and did not receive radiation then. Her recurrent disease was a bulky pelvic mass that melted away with treatment.
Answer from: Radiation Oncologist at Community Practice
Despite having a complete response to chemoimmunotherapy, I would tend toward adjuvant RT since this was a local recurrence.
We don't have long-term data with chemoimmunotherapy in this locally recurrent setting.
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Answer from: Radiation Oncologist at Community Practice
I would add RT, as the goal is still curative and we have not replaced the value of local treatment with systemic alone. Plus, we don't have data on the long-term durability of this complete response.