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For a patient with unresectable EGFR positive lung adenocarcinoma treated with chemoradiation and a single site of oligometastasis treated definitively, would you consider durvalumab as per PACIFIC study or EGFR-directed therapy?

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Mednet Member

Medical Oncology · UCSD Moores Cancer Center

Technically, this is metastatic disease so I would do osimertinib here. I would avoid antiPD1 in known EGFR in metastatic setting due to pneumonitis risk when you have to start the EGFRi eventually