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For a woman with baseline neuropathy, is there any evidence to use a different chemotherapy with atezolizumab in metastatic triple negative breast cancer?

1 Answer
Mednet Member
Medical Oncology · Inova Schar Cancer Institute
Answered on

Unfortunately, there is no published clinical trial evidence for using atezolizumab with chemotherapies other than nab-paclitaxel. There are ongoing trials, such as IMpassion132, but they have not reported results. Trials presented at ASCO 2019 include COLET (atezolizumab plus cobimetinib with either paclitaxel or nab-paclitaxel) and a trial of pembrolizumab with either capecitabine or paclitaxel, but these were both very small trials that have not been published in peer-reviewed literature yet. Therefore, for now, atezolizumab can only be recommended with nab-paclitaxel in PDL1 positive metastatic TNBC.

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