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For a young, fit patient with newly diagnosed Stage IV high risk (IPI >2) DLBCL - germinal center subtype, what would be your preferred treatment approach in light of the FRONT-mind trial comparing Tafa-Len-RCHOP vs RCHOP?

With the recent publication of the FRONT-mind trial comparing Tafa+Len+RCHOP vs. RCHOP showing and 8% PFS benefit without an overall survival benefit, which patients are you using this new regimen in compared to Pola-RCHP or RCHOP alone?
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For a young, fit patient with newly diagnosed Stage IV high risk (IPI >2) DLBCL - germinal center subtype, what would be your preferred treatment approach in light of the FRONT-mind trial comparing Tafa-Len-RCHOP vs RCHOP?

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