For an otherwise healthy post-menopausal woman with early stage HR+ BC and persistent AI intolerance, is there an age cutoff above which you would consider avoiding adjuvant tamoxifen therapy?

There is no age cut-off based on chronological age. However, physiologic age and comorbid conditions are what I would use. For example, a 72 yo with diabetes, hypertension, and coronary artery disease is likely to die of her underlying conditions and not early stage breast cancer (Ording et al., PMI...