For concurrent chemoradiation in head and neck cancers, how important is the timing of weekly radiosensitizing cisplatin early versus late in the week?
Specifically with reference to rural settings where the logistics of early in the week delivery may be more challenging.
Answer from: Radiation Oncologist at Academic Institution
I do not know but suspect that it doesn't make much of a difference as long as it is concomitant.
Answer from: Medical Oncologist at Community Practice
Interesting question, but there have been no trials looking at day of the week for cisplatin infusion. While starting with cisplatin prior to radiation on Monday makes theoretical sense, there are logistic barriers that are not specific to institutions or organizations.
The pharmacokinetics of cisp...
Comments
Radiation Oncologist at Genesis Healthcare Partners- San Diego
I have preferred weekly chemo instead of q 3 weeks...
I have preferred weekly chemo instead of q 3 weeks...
Answer from: Radiation Oncologist at Community Practice
Interesting comment by @Banu E. Symington. Back in the late 90's and early 2000's, as I recall, there was a series of articles by Branislav Jeremic discussing the results of cisplatin administered daily at a dose of (if memory serves) 6 mg/m2/day in a variety of settings including H&N cancer, an...
Thank you for your reply. So with the pharmacokine...
Agree, implying that RT should be delivered 1-2 ho...
Thanks.