For HPV-negative head and neck cancer of unknown primary after proper work up and biopsies, what mucosal surface(s) do you cover?

The treatment for CUP has evolved quite a bit, and frankly, I don't think there is a true standard. Even in our group, we often don't have consensus with regards to whether to even treat mucosa and if treating, which sites.

Very weak data suggests that whether you just treat the involved neck or chas...

Assuming the patient is a heavy smoker, EBV- and Caucasian, I would cover the nasopharynx bilaterally (EBV- NPC in an Asian patient is less likely), ipsilateral oropharynx, whole supraglottic larynx, and ipsilateral hypopharynx. While the oral tongue and buccal mucosa are theoretically at risk, I wo...

Oropharynx and nasopharynx