For low/intermediate essential thrombocythemia not on cytoreduction, would you temporarily cytoreduce in anticipation of surgery?

First, I am going to answer this question with a question. What is low/intermediate essential thrombocytosis (ET)? I ask this question because we are living in the 21st century in the midst of the genomic era, and it is far past the time that we should be dwelling on phenotype instead of employing precision hematology in the clinic using genotype. Of course, the concept of “low/intermediate essential thrombocytosis" is a figment of the imagination of individuals still dwelling in the past.

ET is one of the myeloproliferative neoplasms (MPN), and as such, it is a disorder of the hematopoietic stem cell (HSC). HSCs are unique since they have only one hematopoietic growth factor receptor, the thrombopoietin receptor (MPL), and yet HSCs are resp...