For metastatic colorectal cancer, is it possible for the tumor to be mismatch repair proficient at primary site but mismatch repair deficient at metastatic site?
Do you routinely test for this with a re-biopsy?
Answer from: Medical Oncologist at Academic Institution
This is a very interesting question, and most of the time we think the MSI/MMR status between the primary site and the metastatic lesion is consistent. However, some studies suggest there could be some inconsistent results in colorectal cancer patient. In a small study with 40 metastatic colore...
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