For newly diagnosed ALK or EGFR + NSCLC with oligometastases to brain only and otherwise cN0-1 thoracic disease, would you offer targeted therapy alone or SRS to brain + concurrent chemoradiation/surgery to chest?

Answer from: Medical Oncologist at Community Practice

For asymptomatic patients with smaller lesions, I would offer initial osimerinib or alectinib and get MRI with SRS planning sequences at 1month. We would then SRS any non-responding lesions

Comments

Medical Oncologist at Penn State Health
@Sandip P. Patel, Thank you for your response. I c...

Medical Oncologist at UCSD Moores Cancer Center
I think oligometastatic consolidative sbrt for a p...

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For newly diagnosed ALK or EGFR + NSCLC with oligometastases to brain only and otherwise cN0-1 thoracic disease, would you offer targeted therapy alone or SRS to brain + concurrent chemoradiation/surgery to chest?

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