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For NSCLC patients treated with neoadjuvant chemoimmunotherapy and surgery with ypN2 disease, what factors would cause you to recommend PORT?

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Mednet Member
Mednet Member
Radiation Oncology · UCLA | VA Greater Los Angeles Healthcare System

This question is a tough one, and the multidisciplinary teams I work with are still trying to figure it out. This is mostly because only 13% (67/501) of randomized participants in the Lung ART study received neoadjuvant chemotherapy, and 0% received neoadjuvant chemoimmunotherapy; all had pN2 or ypN...

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Mednet Member
Mednet Member
Radiation Oncology · Duke University Medical Center

Agree with Dr. @Dr. First Last that this is a tough question.

I have recommended PORT less and less often since the publication of Lung ART. However, there are a few indications where I think postoperative RT still makes good oncologic sense after neoadjuvant chemoimmunotherapy and surgery. One situa...

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