For patients with advanced gastric/GEJ cancer expressing PDL1, is there data to support frontline pembrolizumab?
What treatment would you offer a newly diagnosed patient with metastatic HER2 negative, MSS esophagogastric adenocarcinoma with PD-L1 CPS 0?
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I agree with Dr. @Dr. First Last's comments regarding the Keynote 059, 061, and 062 studies.
However, there are new data presented at the 2020 ESMO meeting.
The Keynote 590 is a phase III study enrolled 749 patients with advanced esophageal and GEJ cancer (including esophageal squamous cell carcino...
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Like tweets from some of our politicians, my previous answer has not aged well. I absolutely agree with Dr. @Dr. First Last that both Checkmate-649 and KEYNOTE-590 have transformed the treatment of esophagogastric cancer (EGC; both adenocarcinoma and SCC). Broadly speaking, there are now phase III d...
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There are no phase III data. The only data so far come from one arm of the KEYNOTE-059 study, where 25 Pts were treated with 5-FU/cisplatin and pembrolizumab (Bang, J Clin Oncol 2017;35:4012 [abstr]). The response rate was 60% and survival data were encouraging. However, in the absence of phase III ...
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I will be in the minority, but I am not sure the available data is convincing to use upfront immunotherapy in most patients with esophageal cancer.
1. KN590 really just mimics the results of KN181: there is some benefit for patients with esophageal SCC with CPS>10.
The benefit in the overall popula...
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