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For patients with endometrial cancer, should tumor size be included as a risk factor for recurrence?

2 Answers
Mednet MemberInvited Expert
Radiation Oncology · University of Kentucky Albert B. Chandler Hospital
Answered on

Tumor size is not currently used in staging for endometrial cancer.

There have been some retrospective studies that suggest a higher rate of local recurrence and recurrence-free survival in patients with endometrial cancer and a larger tumor size (>2-2.5 cm). (Sozzi et al., PMID 29489475) (Han et al., PMID 28538399). However, other studies show that tumor size was not a risk factor predicting recurrence in patients with stage I or II endometrioid type endometrial cancer who had lymphadenectomy. (...

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Mednet Member
Radiation Oncology · Vanderbilt-Ingram Cancer Center
Answered on

I think Dr. @Dr. First Last has made a number of good points.

My only thought is that for folks who have medically inoperable endometrial cancer, they don't really have an alternative option for definitive intent management. So while tumor size may be indirectly prognostic of a chance of success, the lack of alternative options (given they should already be medically inoperable) means one should push forward anyways, and I can't think of a situation where I would withhold curative intent therapy ...

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