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For patients with locally advanced EBV-associated nasopharyngeal carcinoma treated with induction gem/cis, what concurrent chemo regimen and scheduling do you typically use during radiotherapy?

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Mednet Member
Mednet Member
Radiation Oncology · University of Texas MD Anderson Cancer Center

Cis/gem induction is based on the paper by Zhang et al., PMID 31150573. They used 100 mg/m² every 3 weeks of cis concurrent. ~ 40% received 3 cycles, 50% 2, and 10% 1. As many have in our concurrent scenarios for HN CA, our medical oncologists prefer the weekly 40 mg/m². There remains no clear 2nd l...

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Mednet Member
Mednet Member
Radiation Oncology · University of Michigan

Cisplatin 100 mg/m² every 3 weeks during RT was the regimen used in the major G-C induction trials, such as Zhang et al., PMID 31150573. The alternatives, 40 mg/m² every week or carboplatin for patients who do not tolerate high-dose cisplatin, are reasonable but do not have the same level of randomi...

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