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For patients with mild CKD, how do you decide between zoledronic acid and denosumab for bone protection in patients with multiple myeloma?

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Mednet Member
Mednet Member
Medical Oncology · University of Chicago

In this scenario, I prefer zoledronic acid every 3 months with renally adjusted dose. In my experience, the risk of hypocalcemia seems higher with denosumab. Calcium/vitamin D supplementation would be important as well. The every 3 month dosing is an advantage over denosumab, which would have to be ...

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For patients with mild CKD, how do you decide between zoledronic acid and denosumab for bone protection in patients with multiple myeloma? | Mednet