For patients with myxoid liposarcoma who needed upfront surgery and had an indication for PORT, would you consider dose reduction/hypofractionation of adjuvant radiation?

Great question. This touches on two distinct but related concepts:

1. Dose Reduction for Myxoid Liposarcoma: The radiosensitivity of myxoid LPS is well established, and dose reduction has been studied, but almost exclusively in the preoperative setting. Prospective data support preoperative doses as lo...

No. I would use this opportunity not to extrapolate DOREMY to a setting it does not address, but rather to discuss with the surgeon regarding the need to refer such patients for multi-disciplinary evaluation prior to surgery.

Regarding conventionally fractionated SIB postop treatment, I would also no...