For patients with Stage IIIB or IV HD flowing Bv-AVEPC with initial large mediastinal adenopathy, how can we avoid ISRT?
Per the NCCN guideline for HR HD, if treated per OEPA-COPDAC, you can omit ISRT. This patient received treatment per AHOD1331, which recommends ISRT for large mediastinal adenopathy.
2 Answers
Mednet MemberInvited Expert
Pediatric Hematology/Oncology · Children’s Wisconsin
Answered on
It is true that on the clinical trial AHOD1331, patients who presented with large mediastinal adenopathy received radiation therapy as did patients who were slow early responders (Deauville 4 or 5 after two cycles of therapy). It is noteworthy that 3-year event-free survival was extremely high for a...
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Mednet Member
Pediatric Hematology/Oncology · University of Saskatchewan
Answered on
Excellent question.
Dr. @Dr. First Last's answer above is informative particularly the remarkable rates of radiation with N-AVD of 0.4%, while maintaining excellent outcomes. That is a preferred approach compared to what I will say next.
The only addition I have: I had a patient with stage IIB with b...
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