For the first-line treatment of metastatic lung adenocarcinoma without a targetable driver mutation, do you routinely add bevacizumab to the chemotherapy backbone in the absence of a contraindication to the drug?
Do you add bevacizumab regardless of whether you are using paclitaxel or pemetrexed with the platinum agent?
Answer from: Medical Oncologist at Academic Institution
That is a really good question. In my practice, I typically will use carboplatin plus pemetrexed for 4-6 cycles followed by maintenance pemetrexed. The addition of bevacizumab consistently improves response rates when added to chemotherapy, so if I have a patient that is symptomatic from local dis...
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Answer from: Medical Oncologist at Academic Institution
I agree with the above and would also add consideration for the phase II BRAIN study showing the utility of bevacizumab in the front line for patients with brain metastases.