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Topics:
Hematologic Malignancies • Pediatric Hematology/Oncology • Aplastic Anemia • Hematology • Bone Marrow Failure • Pediatric Hematology
For transplant-ineligible aplastic anemia planned for immunosuppression, how do you approach duration and tapering of cyclosporine and eltrombopag?
How do you decide between 6 vs 12 months of therapy, or longer? And how often are you changing doses of these drugs when tapering?
Answer from: at Academic Institution
One of the most common mistakes in the management of AA is premature tapering of cyclosporine or tacrolimus. If there is a complete remission, and by that I mean normalization of counts, not complete remission as defined in some papers (e.g., ANC 1000, Plts 100,000, Hb 10 as in de Latour et al., PMI...
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