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For transplant-ineligible aplastic anemia planned for immunosuppression, how do you approach duration and tapering of cyclosporine and eltrombopag?

How do you decide between 6 vs 12 months of therapy, or longer? And how often are you changing doses of these drugs when tapering?
1 Answer
Mednet Member
Mednet MemberInvited Expert
Hematology · Dana-Farber Cancer Institute
Answered on

One of the most common mistakes in the management of AA is premature tapering of cyclosporine or tacrolimus. If there is a complete remission, and by that I mean normalization of counts, not complete remission as defined in some papers (e.g., ANC 1000, Plts 100,000, Hb 10 as in de Latour et al., PMI...

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