For unresectable radiation induced angiosarcoma, what dose and fractionation would you use?
Angiosarcoma is invading the brachial plexus and thoracic vertebral bodies.
Prior radiation therapy: Radiation to the left chest wall and regional nodes (including SCV) 30 years ago
2 Answers
Mednet MemberInvited Expert
Radiation Oncology · University of Florida
Answered on
45 Gy at 1 Gy TID with 10 cm margins, boost to 60 Gy with same fractionation with 5 cm margins. If still incompletely resectable, 75 Gy. Outcomes have been published by NPM.
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Mednet MemberInvited Expert
Radiation Oncology · The Ohio State University - James Cancer Hospital and Solove Research Institute
Answered on
If localized, would start with taxane-based chemo. This may downstage the tumor a bit and will provide a window of chemoselection to prove the patient isn't going to develop early metastatic disease that would make local therapy futile. Once response plateaus or toxicity mounts, conventionally fract...
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