For unresectable radiation induced angiosarcoma, what dose and fractionation would you use?

Angiosarcoma is invading the brachial plexus and thoracic vertebral bodies.

Prior radiation therapy: Radiation to the left chest wall and regional nodes (including SCV) 30 years ago

Answer from: Radiation Oncologist at Academic Institution

45 Gy at 1 Gy TID with 10 cm margins, boost to 60 Gy with same fractionation with 5 cm margins. If still incompletely resectable, 75 Gy. Outcomes have been published by NPM.

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Radiation Oncologist at Ohio State University James Cancer Center
Dr. @William M. Mendenhall - curious, what cord (a...

Radiation Oncologist at University of Florida
Presume that you are referring to RT induced breas...

Radiation Oncologist at Ohio State University James Cancer Center
Many thanks. The OP here mentions tumor invading t...

Answer from: Radiation Oncologist at Academic Institution

If localized, would start with taxane-based chemo. This may downstage the tumor a bit and will provide a window of chemoselection to prove the patient isn't going to develop early metastatic disease that would make local therapy futile. Once response plateaus or toxicity mounts, conventionally fract...

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Radiation Oncologist at CCare
What are the usual cord re-irradiation constraints...

Radiation Oncologist at Ohio State University James Cancer Center
Nieder et al., PMID 17084560 As a cross-check, I ...

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