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Given RADICALS-HD, are you completing 24 mo vs 6 mo of ADT with XRT following RP?

RADICALS-HD trial (ESMO 2022) demonstrated metastasis free survival benefit with 24 months compared to 6 months of ADT.
2 Answers
Mednet Member
Mednet MemberInvited Expert
Radiation Oncology · Levine Cancer Institute
Answered on · Updated on

Initial: We know 2 years of ADT works. Adding to the classic RTOG 9601, RADICALS-HD demonstrated an improvement in the primary and clinically-relevant endpoint of MFS.

Who should be offered 2 years is a more nuanced question. I rely heavily on the PSA to guide as I am influenced by the significant in...

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Mednet Member
Mednet Member
Radiation Oncology · Vanderbilt-Ingram Cancer Center
Answered on

I very much struggle to make sense of what to do with RADICALS-HD since 43% of patients received RT in the adjuvant setting and most of them received RT to the prostate bed alone, both of which are no longer SOC (at least assuming PSA > 0.34 as per RTOG 0534). The 'standard' arm of 6 months would no...

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