Given the biochemical failure definition of PSA nadir+2 ng/mL, how do you approach a PSA bounce of magnitude 2 ng/mL or higher?

If a PSA bounces >2 points then PSA decreases subsequently without any treatment, I do *not* consider these patients to have failed. This does occur in the clinic occasionally.

Thankfully, when patients have rising PSAs after RT, there usually is not an urgency to start salvage treatment. When a pat...

ASTRO definition of biochemical failure has high specificity (about 80%) and high negative predictive value ( 90%) but lower sensitivity and positive predictive value (40% or so) . It is good for reporting to avoid incorrect reporting. A PSA bounce can effect the less than 2 years reporting numbers....