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Given the mixed evidence for N-acetylcysteine in adolescent cannabis use disorder, how do you approach discussing this with families?

Do you ever incorporate it into treatment, and if so, in what clinical contexts?
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Which pharmacologic agents, if any, have you trialed in the treatment of cannabis use disorder?

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3 Answers
Mednet Member
Mednet Member
Psychiatry · Private Practice
Answered on

A thoughtful addition to the discussion on NAC in adolescents with cannabis use disorder is to emphasize how and when it is used. In many young patients, cannabis use is not simply recreational or oppositional, but a compulsive attempt to manage obsessional anxiety. When this pattern is recognized—p...

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Mednet Member
Mednet MemberInvited Expert
Psychiatry · Duke University
Answered on

The use of treatments with limited evidence and without FDA approval always raises challenges. NAC has shown mixed and often negative results in studies. Still, if families are interested in trying an alternative option, it’s important to share the evidence that does exist.

For adolescents seeking h...

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Mednet Member
Mednet Member
Psychiatry · Next Step 2 Mental Health
Answered on

Is anyone considering or using natural (and wholly legal) hemp as a harm reduction measure for Cannabis Use Disorder (contains no more than 0.3% THC and primarily CBD), of course, assuming good quality-control measures to ensure it is what the company says it is? Theoretically, this takes out the ps...

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