Given the PATRIOT trial and hypo-FLAME 2.0, do you consider once-a-week prostate SBRT instead of every other day?

Yes, it is reasonable to offer weekly prostate SBRT to patients.

Quick review of evidence:

hypo-FLAME 2.0 (De Cock et al., PMID 37178932) was a phase II single-arm trial that used 35 Gy/5 fx with FLAME-style isotoxic SIB up to 50 Gy/5 fx to visible tumor(s) with a bi-weekly schedule. N=124 participan...