What is your approach for persistent and romiplostim-refractory thrombocytopenia after temozolomide with radiation in a patient with recurrent GBM?
If bone marrow biopsy is unrevealing, would you consider fostamatinib if an immune-mediated mechanism is suspected, or would you favor another approach?
1 Answer
Mednet MemberInvited Expert
Neurology · MD Anderson Cancer Center
Answered on
Even if bone marrow does not show leukemia, I would consider checking for CHIP or CCUS variants. I would probably not have a high index of suspicion for immune-mediated thrombocytopenia related to TMZ in this context. Beyond transfusion, time, TPO-RA, and supportive care, I am not sure there are man...
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