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Has the recent large observational data suggesting that continuing metformin during hospitalization is associated with lower post-discharge mortality and hypoglycemia changed your approach to holding it on admission in stable, non-critically ill patients with T2DM?

Gallo et al., PMID 39900873
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Has recent observational data linking continued metformin use during hospitalization to lower post-discharge mortality and reduced hypoglycemia changed your approach in stable, non-critically ill patients with type 2 diabetes?

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1 Answer
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Hospital Medicine · VA Boston Healthcare System
Answered on

I really like this paper, but I don't think it is plausible that a 5-day difference in receipt of metformin (the median length of stay was 5 days) could really affect 90-day mortality.

The study question is a good one because the evidence that metformin causes lactic acidosis is extremely limited. In...

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