Have the 10-year results from UK FAST-Forward impacted your practice with regard to patient selection?
Do all patients getting whole breast radiation now get 5 fractions? Any concerns of 5 fractions and concurrent systemic therapies such as Kadcyla or Pembrolizumab? What is your preferred boost dose?
2 Answers
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Radiation Oncology · Mayo Clinic Hospital
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I would consider our practice at Mayo as early adopters of ultra-hypofractionation for breast, largely driven by similar institutional trials for shorter courses and the patients we care for. As a result, we have pretty routinely offered 26 Gy/5 fraction whole breast RT since the 5-year follow-up wa...
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Radiation Oncology · Varian Medical Systems/Allegheny health network
Answered on
For us, for most node negative patients, the standard is 5 fractions (APBI or whole breast based on technical or tumor factor); if they need boost after whole breast we use 10 Gy in 4 fractions.
Have not done 5 fractions for those who need concurrent systemic treatment and use 40 in 15 with boost. M...
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