Have the 10-year results from UK FAST-Forward presented at ESTRO 2025 impacted your practice with regard to patient selection?

Do all patients getting whole breast radiation now get 5 fractions? Any concerns of 5 fractions and concurrent systemic therapies such as Kadcyla or Pembrolizumab? What is your preferred boost dose?

Answer from: Radiation Oncologist at Academic Institution

I would consider our practice at Mayo as early adopters of ultra-hypofractionation for breast, largely driven by similar institutional trials for shorter courses and the patients we care for. As a result, we have pretty routinely offered 26 Gy/5 fraction whole breast RT since the 5-year follow-up wa...

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Radiation Oncologist at Indiana University Health
For which patients would you prefer a simultaneous...

Radiation Oncologist at Allegheny Health Network, Pittsburgh
If a patient needs a boost (I am using less and le...

Radiation Oncologist at Mayo Clinic Hospital
I also am now tending to prefer integrated boosts ...

Answer from: Radiation Oncologist at Community Practice

For us, for most node negative patients, the standard is 5 fractions (APBI or whole breast based on technical or tumor factor); if they need boost after whole breast we use 10 Gy in 4 fractions. Have not done 5 fractions for those who need concurrent systemic treatment and use 40 in 15 with boost. ...

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Have the 10-year results from UK FAST-Forward presented at ESTRO 2025 impacted your practice with regard to patient selection?

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