Have you been able to safely use other bisphosphonates in patients who developed an allergic reaction (angioedema) to fosamax?

Hypersensitivity with urticaria in someone on alendronate is quite rare. I am not aware of any publications showing another bisphosphonate safely used in this setting. Although there are significant chemical differences between the various oral and IV bisphosphonates, I personally would avoid the entire class of bisphosphonates in a person with urticaria that I thought was due to alendronate. There are alternatives including denosumab and anabolics that could be used if the patient has significa...